Healing, hormones & brain
CJC-1295 (no DAC)
Modified GRF (1-29)
A modified growth-hormone-releasing hormone. The no-DAC version is short-acting.
What it is
A synthetic version of the first 29 amino acids of growth-hormone-releasing hormone (GHRH), altered to resist breakdown. 'DAC' is a chemical add-on that makes the peptide last for days. The version without DAC lasts roughly half an hour.
How it's thought to work
It signals the pituitary gland to release growth hormone, which raises IGF-1 levels.
What the evidence shows
The DAC version raised growth hormone and IGF-1 for several days in small human studies in 2006, but clinical development stopped. The no-DAC version has very little published human research.
Regulatory status
Not approved for any use. Prohibited by WADA. Tesamorelin is the only approved medicine in this class.
Safety notes
Raising growth hormone can affect blood sugar and cause fluid retention. Long-term safety is unknown.
Key sources
- Teichman SL, et al. Prolonged stimulation of growth hormone and IGF-I secretion by CJC-1295. J Clin Endocrinol Metab. 2006. Find on PubMed
Educational summary only, not medical advice. Gtides does not sell or link to sellers of CJC-1295 (no DAC) or any other product. Products sold as “research peptides” are not approved medicines, and their contents, purity and sterility are not verified.